CoQ10 is a substance that is naturally made in the body that plays an important role in cellular energy production. CoQ10 also has antioxidant effects.
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Studies have shown that supplementation with CoQ10 may have a number of beneficial heart-related effects, including decreasing cholesterol oxidation and improving the function of the lining of blood vessels.
Talk to your healthcare provider if you are concerned about any side effects you experience.
What is CoQ10?
CoQ10, also called ubiquinone, is a substance that is naturally produced by the body. It is most prevalent in the liver, kidney, heart, and pancreas but it can be produced by all cells and does not need to travel through the bloodstream. CoQ10 functions as an important part of cellular energy production and is necessary for the production of adenosine triphosphate (ATP), the main energy molecule in cells. CoQ10 also has important antioxidant activity and may have a role in preventing damage to cells when oxygen levels are too low (1).
What are the health benefits of CoQ10?
CoQ10 is sold as a supplement and has a number of purported health benefits. While many studies have been done on CoQ10, most of them have shown that supplementation likely does not have a significant effect. In other cases, there isn’t enough evidence to draw a definite conclusion. A few conditions for which CoQ10 has been studied include male infertility, migraines, and blood pressure (4). One study did find that supplementation with CoQ10 can improve muscle pain associated with taking statin medications (5) but other studies have had varied results, so there is not enough information to recommend CoQ10’s use for this purpose.
CoQ10 may have the following health benefits, which is why it was chosen to be an ingredient in the Roman Dailies:
A review of studies pointed out that CoQ10 may have a number of beneficial effects regarding heart health. CoQ10 has been shown to decrease the oxidation of cholesterol. CoQ10 also improves the function of the lining of the blood vessels, which is important for maintaining healthy blood pressure and cardiovascular health. And due to its antioxidant properties, CoQ10 lowers the levels of a certain inflammatory chemical called interleukin 6 (2).
Another study investigated the effects of CoQ10 supplementation in patients with chronic heart failure. The patients were given 100 mg three times per day for two years in addition to their usual treatment. Only 15% of the patients stayed in the study until the two-year time point. The study found that the patients who received supplementation had improved symptoms and a reduced number of major cardiovascular events (3).
What doses of CoQ10 have been studied?
Nutritional supplements, like CoQ10, are not reviewed by the FDA for safety and effectiveness. There is no established ideal dosage of CoQ10 and studies have tested a wide range of dosages. Standard dosages that are available for purchase range from 100–200 mg per day.
In what forms is CoQ10 available?
CoQ10 is commonly sold as a supplement in capsule or tablet form.
How does Roman offer CoQ10?
Roman obtains CoQ10 from a non-GMO source in China that makes it synthetically.
Roman offers CoQ10 in the following supplements:
CoQ10 is one of seven main ingredients in Roman’s Heart Health supplement. The supplement consists of four tablets and two fish oil softgels that should be taken with water. Each individual tablet contains 50 mg of CoQ10, for a total daily dose of 200 mg.
Other ingredients in the tablets include spirulina whole plant powder, deodorized garlic bulb powder, magnesium citrate, menaquinone-7, cholecalciferol, microcrystalline cellulose, dicalcium phosphate, stearic acid, croscarmellose sodium, magnesium stearate, silicon dioxide, and pharmaceutical glaze (shellac, povidone). Ingredients in the fish oil soft gels include marine lipid concentrate, gelatin, glycerin, purified water, and mixed tocopherols. The softgels contain fish and should not be consumed by anybody with a fish allergy.
What are the side effects of taking CoQ10?
CoQ10 is generally well tolerated. When side effects do occur, they are mild and include insomnia and gastrointestinal complaints such as nausea, diarrhea, and appetite suppression (1).
Does CoQ10 interact with any other drugs?
CoQ10 interacts with several other medications. If you are taking any of the following medications, it is important you talk to your healthcare provider before beginning CoQ10 supplementation (please note that this list may not be exhaustive and other medications may also interact with CoQ10) (1):
- Warfarin (brand name Coumadin)
- Some types of cancer treatments
Roman’s Heart Health supplement contains fish and should not be consumed by anybody with a fish allergy.
- Coenzyme Q10. Memorial Sloan Kettering Cancer Center. https://www.mskcc.org/cancer-care/integrative-medicine/herbs/coenzyme-q10. Published August 2, 2019. Accessed November 18, 2019.
- Durante A, Bronzato S. Dietary supplements and cardiovascular diseases. International Journal of Preventive Medicine. 2018;9(1):80. doi:10.4103/ijpvm.ijpvm_179_17.
- Mortensen SA, Rosenfeldt F, Kumar A, et al. The Effect of Coenzyme Q 10 on Morbidity and Mortality in Chronic Heart Failure. JACC: Heart Failure. 2014;2(6):641-649. doi:10.1016/j.jchf.2014.06.008.
- NCCIH. National Center for Complementary and Integrative Health. https://nccih.nih.gov/health/coq10. Published January 2019. Accessed November 18, 2019.
- Qu H, Guo M, Chai H, Wang WT, Gao ZY, Shi DZ. Effects of Coenzyme Q10 on Statin‐Induced Myopathy: An Updated Meta‐Analysis of Randomized Controlled Trials. Journal of the American Heart Association. 2018;7(19). doi:10.1161/jaha.118.009835.