Cold sores treatment

Be prepared to take action at the first symptom. If you are currently experiencing an outbreak, hear back from a doctor within 24 hours and, if approved, get free 2-day shipping. Get peace of mind and the treatment you need without the uncomfortable trips to the pharmacy.

Get your first month of treatment free on a quarterly plan, if approved.

Free online visit

Treatment overview

Free 2-day shipping

Prescription medication

Ongoing care + free follow ups

No commitment / cancel anytime

What are cold sores?

Oral herpes (also known as cold sores) are painful sores on or around the lips caused by HSV-1 (and rarely HSV-2).

Can it be treated?

Yes. We’ll give you accurate information, personalized treatment with scientifically-proven medication, and ongoing care to help you treat outbreaks.


Valacyclovir (generic Valtrex)

did you know

48% of Americans ages 14–49 have oral herpes.

View source

Treatments for cold sores

In order to receive treatment for oral herpes (cold sores) through Roman, you need to have already received an in-person diagnosis from a doctor. If treatment is appropriate for you, we’ll ship your medication in discreet, unmarked packaging.

Valacyclovir (generic Valtrex)

Our physician in residence, Dr. Michael Reitano, was the lead author on a landmark study on valacyclovir, one of the leading prescription medications used to treat oral herpes (cold sores).

Transparent manufacturing

Valacyclovir manufactured by Camber, Cadista, and Cipla in India.


Generic Valtrex

Get treated Important safety information

Valacyclovir isn’t safe for some people and others may need a lower than normal dose to use valacyclovir safely. Tell your doctor if you have kidney disease or if your immune system isn’t normal because of a bone marrow or kidney transplant or HIV. Common side effects of valacyclovir include headache, nausea, and abdominal pain. There is no cure for herpes, and even with treatment it may be possible to spread herpes.

What to expect

Valacyclovir will get to work as soon as the medication is in your system, but the time it takes to see noticeable results varies from person to person.

Treatment updates

If you still don’t see results, your doctor may be able to recommend a different treatment plan.

Help with side effects

If you experience adverse side effects, message your doctor and they’ll help determine if a different treatment approach is better for you.

Let’s take care of it

Cold sores can be more than just annoying. They can be disruptive to your life and a risk to your partner’s health. You can take control of outbreaks with the right information, treatment plan, and scientifically-proven medication. We’re here to help.

1. Online visit

Report your symptoms and medical history to a US-licensed physician for evaluation.

2. Free deliveries

Your treatment will be sent in discreet packaging, always with free 2-day shipping.

3. Ongoing care

Send your doctor a message any time to discuss updating your treatment, solving for side effects, or any other questions or concerns.


For more information about Roman, Ro and more, visit our FAQ page. To speak to a care representative, give us a call at (888) 798-8686 or email us at [email protected].

How does cold sore (oral herpes) treatment with Roman work?

We use telemedicine technology and U.S. licensed doctors to provide cold sore treatments discreetly, conveniently, and inexpensively.

It starts with your online doctor visit. Your doctor needs to know about your health (e.g., your medications, lifestyle issues, prior surgeries) and how cold sores affect you.
They also need personal ID so they know who they will be helping in the coming year. They review everything, determine if you’re a candidate for telemedicine and, if so (most people are), they will craft a personalized treatment plan.

Their treatment plan will include a great deal of information about oral herpes. It is important you take the time to read it all. You will be better prepared to manage your condition as a partner—and not just a patient.

If you qualify, our doctors will provide prescribe the right course of treatment to help you take control of cold sore outbreaks.

What type of cold sore medication do you prescribe?

Our physicians prescribe valacyclovir (generic Valtrex) to treat cold sores (oral herpes). When used properly, this medication can abort an outbreak at the first sign that one is coming on or lessen its severity. See important safety information.

Is there suppressive therapy for cold sores?

Your doctor may prescribe valacyclovir for cold sore suppressive therapy. This is an off-label use of the drug, which means that the FDA hasn’t yet approved valacyclovir as a suppressive treatment for cold sores. Physicians are allowed to prescribe FDA-approved medications for off-label uses if they think it is the best course of treatment for their patient. Talk to your doctor if you have any questions about using valacyclovir for cold sore suppression.

The Roman pharmacy can fill valid prescriptions for valacyclovir written by Roman-affiliated physicians. Through the Roman pharmacy, 500 mg tablets of valacyclovir cost $0.97 per day or $87 for a 3 month plan ($29 per month) and 1000 mg tablets cost $1.60 per day or $144 for a 3 month plan ($48 per month).

Is cold sore medication effective?

Cold sore (oral herpes) medication is available, and it works extremely well. But it requires you to dedicate the time to learn about your condition and work with your physician to craft the ideal, personalized treatment plan.

When you do, you’ll be able to identify your specific symptoms (prodrome) and use your medication to shorten or stop the outbreak from occurring. See important safety information.

What are the side effects of cold sore medication?

What follows is a summary and does not include every side effect possible.
Common side effects include headache, feeling sick, dizziness, vomiting, diarrhea, skin reaction after exposure to sunlight (photosensitivity), rash, or itching (pruritus).

Uncommon side effects include feeling confused, seeing or hearing things that aren’t there (hallucinations), feeling very drowsy, tremors, or feeling agitated, shortness of breath (dyspnea), stomach discomfort, rash, sometimes itchy, hive-like rash (urticaria), low back pain (kidney pain), blood in the urine (hematuria), reduction in the number of blood platelets which are cells that help blood to clot (thrombocytopenia), reduction in the number of white blood cells (leucopenia), increase in substances produced by the liver.

Rare side effects include unsteadiness when walking and lack of coordination (ataxia), slow, slurred speech (dysarthria), fits (convulsions), altered brain function (encephalopathy), unconsciousness (coma), confused or disturbed thoughts (delirium), kidney problems where you pass little or no urine. Lastly, watch out for a severe allergic reaction (anaphylaxis). These are rare in people taking Valtrex. Anaphylaxis is marked by the rapid development of flushing, itchy skin rash, swelling of the lips, face, neck, and throat—causing difficulty in breathing (angioedema), fall in blood pressure leading to collapse. If any of these occur, get emergency treatment immediately. See important safety information.

Can a doctor treat cold sores remotely?

Yes. Our doctors can prescribe medication and help you dial in the most effective treatment plan for your unique needs.

Physicians on the Ro platform use telemedicine technologies to treat cold sores in the same way they treat patients in-person. Doctors ask you questions to evaluate your symptoms and make sure it’s safe and appropriate to prescribe cold sore medication. The physicians on the Ro platform use your answers to assess your condition and create a treatment plan. That’s why it’s vital you answer each question to the best of your knowledge and ensure that every communication with your physician is truthful, accurate, and thorough.