Plenity is the first and only FDA-cleared weight management tool made from naturally derived building blocks. In clinical trials, 59% of Plenity responders lost on average of 10% of their body weight (22 pounds) in six months. Plenity is indicated to aid weight management in adults with excess weight or obesity, Body Mass Index (BMI) of 25 to 40 kg/㎡, when used in conjunction with diet and exercise.

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Treatment benefits

Stimulant free and non-habit forming

Clinically-tested and FDA-cleared

Free 2-day shipping

Free and unlimited follow-ups

How it works

Plenity, made from naturally derived building blocks, is three capsules taken with 16 ounces (2 cups) of water before lunch and dinner. Plenity absorbs the water you drank and mixes with the food you eat. This makes you feel full and helps you eat less. With continued use, you’ll feel fuller throughout the day.

Take 3 capsules

Take three Plenity capsules before lunch and again before dinner.

Drink 16 ounces of water

Don’t just take a sip—for the capsules to take effect, you need to drink 16 oz of water with each dose.

Wait 20 minutes

You’re ready to enjoy your meal and feel full after eating smaller portions.

Why Plenity


Nearly 60% of study participants that were treated with Plenity achieved an average weight loss of 10% of their body weight or ~22 pounds.

Proven safety profile

A clinical study showed that Plenity is as safe and tolerable as a placebo (a capsule with inactive ingredients), with minor side effects.


Plenity is not a stimulant and there are no restrictions for how long it can be used.


Plenity is safe for use by people with or without other conditions such as hypertension, type 2 diabetes, or dyslipidemia.

*The percentage of responders, a co-primary endpoint, or the percentage of patients who lost 5% of body weight, achieved clinically meaningful weight loss with Plenity vs placebo (59% vs 42%; P=0.0008). The study did not meet the predefined weight loss super-superiority margin of 3% over placebo.

Learn more about Plenity’s clinical trial—Gelesis loss of weight (GLOW) study

In a 24-week clinical trial called GLOW (Gelesis Loss of Weight), Plenity or placebo was given to 436 adults who were overweight or had obesity, in conjunction with diet and exercise. 

The study was designed to measure: efficacy of at least 35% of individuals receiving Plenity lost 5% of their body weight, and a Placebo-adjusted weight loss of 3%. 

There was no difference between placebo and Plenity in the overall incidence of adverse events.

Important Safety Information

Patients who are pregnant or are allergic to cellulose, citric acid, sodium stearyl fumarate, gelatin, or titanium dioxide should not take Plenity.

To avoid impact on the absorption of medications:

  • For all medications that should be taken with food, take them after starting a meal.
  • For all medications that should be taken without food (on an empty stomach), continue taking on an empty stomach or as recommended by your physician or nurse practitioner.

Contact a doctor right away if problems occur. If you have a severe allergic reaction, severe stomach pain, or severe diarrhea, stop using Plenity until you can speak to your doctor.

Plenity is a prescription-only therapy. For the safe and proper use of Plenity, talk to a healthcare professional or refer to the Instructions for Use.