Plenity is the first and only FDA-cleared weight management product made from naturally derived building blocks. Nearly 6 out of 10 people who took Plenity lost at least 5% of their body weight, when taken in conjunction with diet and exercise. Average weight loss was 10% (about 22 pounds).
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For the time being, Plenity will not be available in Florida or Virginia.
Plenity responders lost 22 pounds, on average
Free follow-ups with a Ro network physician
Clinically tested and FDA-cleared
Stimulant free and non-habit forming
How it works
Plenity is a capsule taken with water before lunch and dinner. Plenity absorbs the water you drank and mixes with the food you eat. This makes you feel full and helps you eat less. With continued use, you’ll feel fuller throughout the day.
Take 3 capsules
Take three Plenity capsules before lunch and again before dinner.
Drink 16 ounces of water
Don’t just take a sip – for the capsules to take effect, you need to drink 16 oz of water.
Wait 20 minutes
You’re ready to enjoy your meal and feel full after eating smaller portions.
Nearly 60% of adults treated with Plenity were responders, achieving an average weight loss of 10% of their body weight or ~22 pounds.
Proven safety profile
A clinical study showed that Plenity is as safe and tolerable as placebo, with few minor side effects.
Plenity is safe for use by people with or without other conditions such as hypertension, type 2 diabetes, or dyslipidemia.
Plenity is not a stimulant and there are no restrictions for how long it can be used.
What is Plenity?
Plenity is surprisingly simple, made from two naturally derived building blocks: cellulose and citric acid. Plenity uses new and exclusive hydrogel technology to create a non-stimulant, non-addictive weight management aid to help you lose weight and keep it off.
Plenity’s clinical trial—
Gelesis Loss of Weight (GLOW) study
In a 24-week clinical trial called GLOW (Gelesis Loss of Weight), Plenity or placebo was given to 436 adults who were overweight or had obesity, with and without type 2 diabetes, in conjunction with diet and exercise. The study was designed to measure: whether at least 35% of individuals receiving Plenity lost 5% of their body weight, whether individuals receiving Plenity lost 3% more of their body weight than individuals receiving placebo. Individuals on Plenity lost on average 6% vs. individuals on placebo, who lost on average 4%. The overall incidence of adverse events was no different between placebo and Plenity.
Important Safety Information
Plenity is indicated to aid in weight management in overweight and obese adults with a Body Mass Index (BMI) of 25 – 40 kg/m^2, when used in conjunction with diet and exercise.
What is the most important information I should know about Plenity?
Patients who are pregnant or are allergic to cellulose, citric acid, sodium stearyl fumarate, gelatin, or titanium oxide should not take Plenity.
To avoid impact on the absorption of medications:
- For all medications that should be taken with food, take them after starting a meal.
- For all medications that should be taken without food (on an empty stomach), continue taking on an empty stomach or as recommended by your physician.
Contact a doctor right away if problems occur. If you have a severe allergic reaction, severe stomach pain, or severe diarrhea, stop using Plenity until you can speak to your doctor.
Plenity is a prescription-only therapy. For the safe and proper use of Plenity, talk to a healthcare professional or refer to the Instructions for Use.
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What is Plenity made of?
Plenity contains a hydrogel made of naturally derived building blocks, which absorbs a significant amount of water once in the stomach. Plenity is made from naturally derived substances: carboxymethyl cellulose (modified cellulose – cellulose is the fiber found in vegetables and plants) and citric acid (found in many fruits like lemons and limes).
How does Plenity work?
When Plenity is combined with water, small Plenity hydrogel particles are formed. Plenity particles are about the size of a grain of salt or sugar. After ingestion, Plenity capsules release thousands of these hydrogel particles and each particle absorbs about 100 times its weight in water. These hydrated hydrogel particles do not clump together, rather they mix with food and promote a sense of fullness.
When will I begin to lose weight?
Weight loss is a gradual process and every experience is different. But on average the sensation of fullness occurs early and is followed a few weeks later by weight loss. In clinical studies, people taking Plenity with diet and exercise had greater weight loss compared to people doing diet and exercise alone as early as 4 weeks.
Who and what is Plenity for?
Plenity has been cleared for use in adults, not in children or adolescents. Plenity aids in weight management for overweight and obese adults with a Body Mass Index (BMI) of 25-40 kg/m^2, when used in conjunction with diet and exercise.
You can calculate your BMI by entering your height and weight into a calculator that can be found at: https://www.cdc.gov/healthyweight/assessing/bmi/adult_bmi/english_bmi_calculator/bmi_calculator.html
What is the likelihood that Plenity will work for me?
In the pivotal GLOW study using Plenity, nearly 60% of participants achieved >= 5% body weight loss and 27% of participants achieved >= 10% body weight loss.
Do I need to be on a specific diet or exercise regimen when taking Plenity?
Having a balanced diet with 30 minutes of daily physical activity is part of a healthy lifestyle. Plenity can work with any diet or nutrition plan and since Plenity makes you feel fuller, eating less can be easier.
Is Plenity a drug?
No. Plenity is not a drug because it is not absorbed into your bloodstream, does not alter the function of your cells or your organs, and is not processed or metabolized by your liver or kidneys. Plenity is made of naturally derived building blocks that work locally in your GI tract, it is never absorbed into your body, and acts mechanically to make you feel full.
Does Plenity contain any common allergens?
Plenity does not contain or produce gluten, soy, wheat, peanuts, shellfish, lactose, dairy, sugar, alcohol, latex, or mercury. Nor does it contain any dyes, preservatives, or ingredients related to Para-Aminobenzoic Acid. Plenity is made from naturally derived substances: carboxymethyl cellulose (modified cellulose – cellulose is the fiber found in vegetables and plants) and citric acid (found in many fruits like lemons and limes).
What are the most common side effects of Plenity?
In the pivotal GLOW study, there was no overall difference between treatment and placebo group. The most common side effects of Plenity were diarrhea 13% (placebo 9%), abdominal distension 12% (placebo 7%), infrequent bowel movements 9% (placebo 5%), and flatulence 9% (placebo 5%). These gastrointestinal side effects were usually mild to moderate in intensity and resolved in a matter of days or weeks.