Erectile DYsfunction / Sildenafil Citrate

Sildenafil citrate

Sildenafil is the generic form of the brand Viagra®. Both medications work similarly in the body.

Viagra® is a type of medication known as a PDE5 inhibitor that is used to treat erectile dysfunction. It comes in several different doses and is taken as-needed.

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Disclaimer: The information provided on this page is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions or concerns about your health, please talk to a doctor.


Sildenafil should be taken without food 30-60 minutes before sex and its effects last up to 6-8 hours.

Serious side effects include an erection lasting more than 4 hours, sudden vision loss in one or both eyes, and sudden hearing decrease or loss. If these occur, seek medical attention immediately.

Talk to your doctor or nurse practitioner about your medical conditions and your medications before taking sildenafil. Do not take sildenafil if you are allergic to its ingredients or if you are already taking nitrates (such as nitroglycerin), street drugs called “poppers” (such as amyl nitrate, amyl nitrite, butyl nitrate), or guanylate cyclase stimulators (such as riociguat).

What is generic for Viagra®?

Viagra® and generic Viagra® both contain the same active ingredient: sildenafil citrate. Sildenafil citrate is a type of medication known as a PDE-5 inhibitor. All forms of sildenafil citrate work the same way in the body but differ in dosage and appearance. Viagra® and generic Viagra® are available in 25 mg, 50 mg, and 100 mg tablets. While the manufacturer of the medication and the appearance of the pills may differ, the active ingredient works the same way in your body.

What is sildenafil citrate?

Sildenafil citrate is the chemical name of the active ingredient in Viagra®. When sildenafil is sold in 25, 50, or 100 mg dosages, it’s called Viagra® or it is the generic for Viagra®. When it is sold in a 20 mg dosage, it is called Revatio or it is the generic for Revatio. Revatio is FDA approved for treating pulmonary hypertension. Both Viagra® and Revatio contain the exact same ingredient (i.e., sildenafil citrate), they simply differ in the strength in which they are produced. Healthcare professionals on the Roman platform have the discretion to prescribe 20 mg sildenafil citrate tablets for ED in doses ranging between 20 mg and 100 mg if they believe that it is an appropriate course of treatment for a particular patient. Sildenafil citrate 20 mg tablets for ED is an off-label usage of the medication. It is up to the medical judgment of the doctor or nurse practitioner to decide if off-label treatment is appropriate for a patient based on his unique medical history, symptoms, and preferences. The Roman Pharmacy Network is able to fill prescriptions for sildenafil citrate 20 mg tablets that are issued by a healthcare professional on the Roman platform.

Sildenafil vs Viagra®

Sildenafil contains the same active ingredient as Viagra®, sildenafil citrate. On our platform, sildenafil is available in 20 mg tablets. Multiple tablets of Sildenafil can be combined to equal doses of 40 mg, 60 mg, 80 mg, and 100 mg. When sildenafil tablets are prescribed in these doses for erectile dysfunction, it is considered off-label use. This is because sildenafil is FDA-approved for pulmonary hypertension, not erectile dysfunction. However, the active ingredient in the medication is the same, and in certain situations, it can be appropriate for providers to prescribe medications off-label, especially if the dosing flexibility allowed by the sildenafil better suits your needs.

How does sildenafil citrate work?

1. In order to understand how sildenafil citrate works to treat ED, it’s important to first understand the basics of how erections work.

2.cGMP causes the corpora cavernosa to relax. Allowing blood to rush into the Cavernosal arteries.

3.While blood rushes into the penis, the veins that drain blood from the penis get compressed causing the increased blood to be trapped in the penis causing an erection.

4. An enzyme called phosphodiesterase-5 breaks down cGMP leading the penis to return to its flaccid state.

5. PDE5 inhibitors (PDE5i), like sildenafil citrate, block this enzyme, leading to higher levels of cGMP and improving the ability to obtain and maintain an erection.

How should I take sildenafil?

Sildenafil should be taken 30–60 minutes before sex. It’s important to take it without a meal because fat in a meal can decrease and delay its absorption, which can lower sildenafil’s effectiveness. Even though the instructions are to take it 30–60 minutes before sex, sildenafil lasts in the body for up to 6–8 hours.

How long does sildenafil take to work?

Sildenafil is a short acting medication with a rapid onset. It should be taken 30–60 minutes before sex, and it reaches peak blood levels in 60 minutes on average. Fat in a meal can delay the effects of sildenafil and also decrease the amount that is absorbed. Remember that sildenafil will not give you a spontaneous erection without sexual stimulation.

How long does sildenafil last?

Sildenafil is a short acting drug with an average half-life of 4–5 hours, which means that half the medicine is gone from the body after 4–5 hours in healthy people. The time that it takes to eliminate sildenafil may be prolonged in older people and people with liver or kidney disease and the drug may work longer in these people.

Common side effects of sildenafil

The most common side effects of sildenafil include headaches, facial flushing, stuffy nose, and upset stomach. Serious side effects that are rare include an erection that will not resolve even after 3–4 hours (priapism), hearing loss, which can be sudden, and vision loss in one or both eyes. For more information about side effects, see sildenafil side effects below.

How to get sildenafil

Sildenafil is one of the medications offered on our platform. In order to determine which medication might be right for you, it’s best to complete the online visit and connect with a US-licensed healthcare provider to further discuss your options. If prescribed, your medication will be mailed directly to your door in discreet packaging.

Does Roman offer genuine Viagra®?

Roman offers genuine, branded Viagra® and generic Viagra® to treat erectile dysfunction (ED) in 25, 50, or 100 mg dosages. Roman also offers sildenafil citrate in 20 mg tablets, which can be prescribed by doctors off-label to treat ED in doses ranging between 20 mg and 100 mg if they find it medically appropriate to do so. The active ingredient, sildenafil citrate, is identical in both medications.

Important safety information

Important safety information