𝛃-sitosterol

𝛃-sitosterol is a type of molecule known as a phytosterol, which is part of the cell membrane of plant cells.

Sourced from the USA

Derived from soy


Available in:

Disclaimer: The information provided on this page is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions or concerns about your health, please talk to a healthcare provider.

What is 𝛃-sitosterol?

𝛃-sitosterol, also spelled beta-sitosterol, is a type of phytosterol. Phytosterols are molecules that make up the cell membranes of plant cells. They are similar to cholesterol, which is found in animals. 𝛃-sitosterol is the most abundant plant sterol in the human diet. It is also present in several traditional medications, including saw palmetto and devil’s claw (4).

What are the health benefits of 𝛃-sitosterol?

There are reports that 𝛃-sitosterol is effective at decreasing cholesterol levels. Because 𝛃-sitosterol is similar to cholesterol, it competes with cholesterol for absorption in the digestive system. One study found that intake of moderate to high doses of phytosterols led to decreased intestinal absorption and increased fecal excretion of cholesterol. It also found that the highest dose of phytosterol (2,059 mg per day) led to a decrease in LDL cholesterol levels (5). 𝛃-sitosterol has also been shown to have anti-inflammatory and pain control effects in animals (4).

𝛃-sitosterol also has the following health benefits, which is why it was chosen to be an ingredient in the Roman Dailies:

Prostate Health

𝛃-sitosterol is best known for its potential ability to relieve urinary symptoms that may affect many men as they age. Specifically, 𝛃-sitosterol has been tested to see if it can improve lower urinary tract symptoms (LUTS). One review from 1999 looked at four different studies on 𝛃-sitosterol in men with benign prostatic hyperplasia (BPH). The review found that supplementation led to improved urinary symptom scores and improved urinary flow. However, 𝛃-sitosterol was not seen to decrease the size of the prostate (6).

What doses of 𝛃-sitosterol have been studied?

Nutritional supplements, like 𝛃-sitosterol, are not reviewed by the FDA for safety and effectiveness. The effective daily dose can therefore only be estimated based on what has been tested in studies. One study looked at the effects of supplementation with 20 mg three times per day (1) while another study looked at the effects of 180 mg in two or three divided doses per day (2).

In what forms is 𝛃-sitosterol available?

𝛃-sitosterol is available on its own in capsule form. Alternatively, 𝛃-sitosterol can be a component of other supplements, such as saw palmetto.

How does Roman offer 𝛃-sitosterol?

Roman obtains 𝛃-sitosterol from a source in the USA. The 𝛃-sitosterol is PCR negative and comes from phytosterols in soy.

Roman offers 𝛃-sitosterol in the following supplements:

Prostate Health

𝛃-sitosterol is one of four main ingredients in Roman’s Prostate Health supplement. The supplement consists of one tablet that should be taken with water. The tablet contains 150 mg of 𝛃-sitosterol.

Other ingredients in the tablet include Pygeum africanum bark extract, lycopene, L-selenomethionine, dicalcium phosphate, microcrystalline cellulose, stearic acid, croscarmellose sodium, magnesium stearate, silicon dioxide, and pharmaceutical glaze (shellac, povidone). The Prostate Health supplement contains soy and should not be consumed by anybody with a soy allergy.

What are the side effects of taking 𝛃-sitosterol?

𝛃-sitosterol is generally well-tolerated, although some gastrointestinal side effects have been reported.

Does 𝛃-sitosterol interact with any other drugs?

𝛃-sitosterol may interact with some cholesterol-lowering medications, in some cases enhancing their effects. For example, one small study found that taking 𝛃-sitosterol along with the medication ezetimibe led to decreased intestinal absorption and increased fecal excretion of cholesterol compared to taking ezetimibe alone (3).

Additional considerations:

Women do not have a prostate and it is unclear what effects Roman’s Prostate Health supplement would have if taken by a woman.

Roman’s Prostate Health supplement contains soy and should not be consumed by anybody with a soy allergy.


Sources

  1. Berges R, Windeler J, Trampisch H, Senge T, Group Ξ’-SS. Randomised, placebo-controlled, double-blind clinical trial of Ξ²-sitosterol in patients with benign prostatic hyperplasia. The Lancet. 1995;345(8964):1529-1532. doi:10.1016/s0140-6736(95)91085-9.
  2. Kobayashi Y, Sugaya Y, Tokue A. Clinical effects of beta-sitosterol (phytosterol) on benign prostatic hyperplasia: preliminary study. Hinyokika Kiyo. 1998;44(12):865-868.
  3. Lin X, Racette SB, Lefevre M, et al. Combined Effects of Ezetimibe and Phytosterols on Cholesterol Metabolism. Circulation. 2011;124(5):596-601. doi:10.1161/circulationaha.110.006692.
  4. Lomenick B, Shi H, Huang J, Chen C. Identification and characterization of Ξ²-sitosterol target proteins. Bioorganic & Medicinal Chemistry Letters. 2015;25(21):4976-4979. doi:10.1016/j.bmcl.2015.03.007.
  5. Racette SB, Lin X, Lefevre M, et al. Dose effects of dietary phytosterols on cholesterol metabolism: a controlled feeding study. The American Journal of Clinical Nutrition. 2009;91(1):32-38. doi:10.3945/ajcn.2009.28070.
  6. Wilt TJ, Ishani A, Macdonald R, Stark G, Mulrow CD, Lau J. Beta-sitosterols for benign prostatic hyperplasia. Cochrane Database of Systematic Reviews. 1999. doi:10.1002/14651858.cd001043.