Disclaimer: This is not medical advice. You and your physician will determine if (and potentially how) you should take Sertraline.


What is Sertraline

Sertraline is a member of the medication class called Selective Serotonin Reuptake Inhibitors (SSRIs). This family of drugs also includes fluoxetine (Prozac), paroxetine (Paxil), citalopram (Celexa), escitalopram (Lexapro), and others. These medications are FDA approved for the treatment of depression and anxiety. One of the side effects of these medications is that men who use them require more time and stimulation to ejaculate. This “side effect” has been studied in men with Premature Ejaculation (PE) and found to be an effective therapy. These medications are recommended by the American Urological Association as a first-line treatment for P.E.

How it Works

Ejaculation is a complex phenomenon that is controlled by the nervous system. Various neurotransmitters are involved in the neural pathways that mediate ejaculation. Among them, dopamine, nitric oxide, and serotonin are important neurotransmitters involved in the neurology of ejaculation. Dopamine excites the neurological circuitry and serotonin and nitric oxide inhibit it. This means that more nitric oxide and/or serotonin can delay the time it takes a man to ejaculate. By inhibiting the reuptake of serotonin in the central nervous system (CNS), more serotonin is available resulting in delayed ejaculation.

Side Effects

The most common side effects of sertraline are nausea, diarrhea, insomnia, dry mouth, dizziness, fatigue, drowsiness, tremor, dyspepsia, hyperhidrosis, ejaculatory dysfunction, erectile dysfunction, and decreased libido. It should be noted that doses that are effective in the treatment of P.E. are often lower than doses used to treat depression and anxiety, which may result in a lower risk of side effects.