Disclaimer: This is not medical advice. You and your physician will determine if (and potentially how) you should take Sertraline.


What is Sertraline

Sertraline is a member of the medication class called Selective Serotonin Reuptake Inhibitors (SSRIs). This family of drugs also includes fluoxetine (Prozac), paroxetine (Paxil), citalopram (Celexa), escitalopram (Lexapro), and others. These medications are FDA approved for the treatment of depression and anxiety.

Sertraline for the Treatment of Premature Ejaculation

One of the side effects of SSRIs is that men who use them require more time and stimulation to ejaculate. This “side effect” has been studied in men with Premature Ejaculation (P.E.) and found to be an effective therapy. These medications are recommended by the American Urological Association (A.U.A.) as a first-line treatment for P.E. You can learn more about the A.U.A.’s recommendation in their Guideline on the Pharmacologic Management of Premature Ejaculation.

Roman-affiliated physicians have the discretion to prescribe sertraline for PE if they believe that it is an appropriate course of treatment for a particular patient. Sertraline for PE is an off-label usage of the medication, and it is up to the medical judgment of the doctor to decide if such treatment is appropriate based on each patient’s unique medical history, symptoms, and preferences. The Roman Pharmacy Network is able to fill prescriptions for sertraline that are issued by  a Roman-affiliated physician.

How it Works

Ejaculation is a complex phenomenon that is controlled by the nervous system. Various neurotransmitters are involved in the neural pathways that mediate ejaculation. Among them, dopamine, nitric oxide, and serotonin are important neurotransmitters involved in the neurology of ejaculation. Dopamine excites the neurological circuitry and serotonin and nitric oxide inhibit it. This means that more nitric oxide and/or serotonin can delay the time it takes a man to ejaculate. By inhibiting the reuptake of serotonin in the central nervous system (CNS), more serotonin is available resulting in delayed ejaculation.